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Index > Protein center > SLAMF1(Gene name) > Human
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  • SLAMF1 (Gene name),
  • Signaling lymphocytic activation molecule (Protein name ),  SLAF1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    SLAMF1(SLAM);
    Protein name:
    Signaling lymphocytic activation molecule;
    Alternative:
    IPO-3;CDw150;
    CD:
    CD150;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts (via cytoplasmic domain) with SH2D1A, and with PTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus H protein and acts as a receptor for this virus.
    Function:
    High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Present on the surface of B-cells and T-cells.
    Protein Attributes:
    Sequence length:
    335
    Sequence:
    50:
    MDPKGLLSLT | FVLFLSLAFG | ASYGTGGRMM | NCPKILRQLG | SKVLLPLTYE | 
    100:
    RINKSMNKSI | HIVVTMAKSL | ENSVENKIVS | LDPSEAGPPR | YLGDRYKFYL | 
    150:
    ENLTLGIRES | RKEDEGWYLM | TLEKNVSVQR | FCLQLRLYEQ | VSTPEIKVLN | 
    200:
    KTQENGTCTL | ILGCTVEKGD | HVAYSWSEKA | GTHPLNPANS | SHLLSLTLGP | 
    250:
    QHADNIYICT | VSNPISNNSQ | TFSPWPGCRT | DPSETKPWAV | YAGLLGGVIM | 
    300:
    ILIMVVILQL | RRRGKTNHYQ | TTVEKKSLTI | YAQVQKPGPL | QKKLDSFPAQ | 
    335:
    DPCTTIYVAA | TEPVPESVQE | TNSITVYASV | TLPES
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    MIM:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Signaling lymphocytic activation molecule
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    E9273d
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    Packing:
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    ELISA Kit for Human Signaling lymphocytic activation molecule
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    ELISA Kit for Human Signaling lymphocytic activation molecule
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    CLIA Kit for Human Signaling lymphocytic activation molecule
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    U9273d
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    Packing:
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    CLIA Kit for Human Signaling lymphocytic activation molecule
    Cat.:
    U9273h
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    Packing:
    96T
    CLIA Kit for Human Signaling lymphocytic activation molecule
    Cat.:
    U9273m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Signaling lymphocytic activation molecule
    Cat.:
    P9273Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Signaling lymphocytic activation molecule
    Cat.:
    P9273Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Signaling lymphocytic activation molecule
    Monoclonal Antibody for Human Signaling lymphocytic activation molecule
    Monoclonal Antibody for Human Signaling lymphocytic activation molecule
    Monoclonal Antibody for Human Signaling lymphocytic activation molecule
    Protein for Human Signaling lymphocytic activation molecule
    Protein for Human Signaling lymphocytic activation molecule
    Protein for Human Signaling lymphocytic activation molecule

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
      tissue: T-cell.
    2. 2.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    5. 5.
      "Absence of SLAM mutations in EBV-associated lymphoproliferative disease patients."
      Ferrand V. , Li C. , Romeo G. , Yin L.
      J. Med. Virol.70:131-136(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 265-288
    6. 6.
      "CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis."
      Mikhalap S.V. , Shlapatska L.M. , Berdova A.G. , Law C.L. , Clark E.A. , Sidorenko S.P.
      J. Immunol.162:5719-5727(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INPP5D
    7. 7.
      "SLAM (CDw150) is a cellular receptor for measles virus."
      Tatsuo H. , Ono N. , Tanaka K. , Yanagi Y.
      Nature406:893-897(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MEASLES VIRUS HN PROTEIN;DOMAIN IG-LIKE V-TYPE
    8. 8.
      "The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM."
      Sayos J. , Wu C. , Morra M. , Wang N. , Zhang X. , Allen D. , van Schaik S. , Notarangelo L. , Geha R. , Roncarolo M.G. , Oettgen H. , de Vries J.E. , Aversa G. , Terhorst C.
      Nature395:462-469(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.1 ANGSTROMS) OF 276-286 IN COMPLEX WITH SH2D1A
    9. 9.
      "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells."
      Morra M. , Lu J. , Poy F. , Martin M. , Sayos J. , Calpe S. , Gullo C. , Howie D. , Rietdijk S. , Thompson A. , Coyle A.J. , Denny C. , Yaffe M.B. , Engel P. , Eck M.J. , Terhorst C.
      EMBO J.20:5840-5852(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 273-286 IN COMPLEX WITH SH2D1B;INTERACTION WITH SH2D1B
    10. 10.
      "A 'three-pronged' binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome."
      Hwang P.M. , Li C. , Morra M. , Lillywhite J. , Muhandiram D.R. , Gertler F. , Terhorst C. , Kay L.E. , Pawson T. , Forman-Kay J.D. , Li S.-C.
      EMBO J.21:314-323(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 276-282 IN COMPLEX WITH SH2D1A
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 276-286 IN COMPLEX WITH SH2D1A AND FYN
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-81
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